Calcification of placenta is a sign of normal degenerative changes taking place in the placenta. This usually happens in the 3rd trimester and is usually of little or no clinical significance. However, if seen earlier (2nd trimster) it might signify placental aging and abnormal degenerative changes. In the ultrasound video attached, there is extensive calcium deposition of the placenta on the maternal surface, (or basal part). Such calcific changes of the placenta do not indicate any placental pathology. See: sonography of placenta for more images and cases.